ProSci

CD273 [PD-L2] Recombinant Protein

Product Code:
 
PSI-90-427
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
Stable for at least 1 year after receipt when stored at -20˚C. Working aliquots are stable for up to 3 months when stored at -20˚C.
 

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PSI-90-427-100ug100ug£657.00
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Further Information

Additional Names:
Programmed Cell Death 1 Ligand 2, PDCD1 Ligand 2, B7-CD, PDL2
Application Note:
This recombinant proteins is for research use only.
Background:
T cells require a signal induced by the engagement of the T cell receptor and a costimulatory signal(s) through distinct T cell surface molecules for optimal T cell activation and tolerance. CD273 (PD-L2) is one of two ligands for programmed death-1 (PD-1; CD279), a member of the CD28 family of immunoreceptors. The other identified ligand is PD-L1. CD273 is broadly expressed and also up regulated in a variety of tumor cell lines. On previously activated T cells, CD273 interaction with PD-1 inhibits TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. CD273 has a costimulatory function on resting T cells activated with suboptimal TCR signals.
Biological Activity:
Measured by its binding ability in a functional ELISA.
Buffer:
Lyophilized from 0.2um-filtered solution in PBS. Reconstitute with 100 μl sterile water. Add 1X PBS to the desired protein concentration.
Fusion Tag:
Fc Tag
NCBI Gene ID #:
80380
NCBI Official Name:
programmed cell death 1 ligand 2
NCBI Official Symbol:
PDCD1LG2
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_079515
Protein GI Number:
190014605
Purity:
>98% (SDS-PAGE).

Endotoxin level is less than 0.06EU/ μg protein (LAL test; Lonza).
Recombinant Protein Sequence:
Thr32-Gly402
Source:
CHO cells
Swissprot #:
P05112

Documents