Antibody Isotype:
Rabbit Ig
Antibody Clonality:
Polyclonal
Applications:- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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This product comes from:
United States.
Typical lead time:
14-21 working days.
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- Further Information
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Further Information
Small ubiquitin-related modifier 4, SUMO-4, Small ubiquitin-like protein 4, SUMO4, SMT3H4
For IHC-P starting dilution is: 1:50~100
For WB starting dilution is: 1:1000
SUMO4 is a member of the SUMO gene family. This family of small ubiquitin-related modifiers covalently modify target lysines in proteins and control the target proteins' subcellular localization, stability, or activity. Upon oxidative stress, SUMO4 conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. This protein may also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to SUMO4 substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. In contrast to SUMO1, SUMO2 and SUMO3, SUMO4 seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90. This may impair processing to mature form and conjugation to substrates. SUMO4 is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. The M55V substitution has been associated with type I diabetes.
- Park,Y., et al. Nat. Genet. 37 (2), 112 (2005)
- Guo,D., et al. Nat. Genet. 36 (8), 837-841 (2004)
- Bohren,K.M.,et al. J. Biol. Chem. 279 (26), 27233-27238 (2004)
- Yang, S.H., et al., Mol. Cell 13(4):611-617 (2004).
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This SUMO4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human SUMO4.
387082
Small ubiquitin-related modifier 4
SUMO4
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
11 kDa
Q6EEV6
81175019
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cell Cycle
Q6EEV6
Optimal dilutions for each application to be determined by the researcher.