Further Information
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, UDP-GlcNAc-2-epimerase/ManAc kinase, UDP-N-acetylglucosamine 2-epimerase (hydrolyzing), UDP-GlcNAc-2-epimerase, Uridine diphosphate-N-acetylglucosamine-2-epimerase, N-acetylmannosamine kinase, ManAc kinase, GNE, GLCNE
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
The protein encoded by this gene is a bifunctional enzyme
that initiates and regulates the biosynthesis of N-acetylneuraminic
acid (NeuAc), a precursor of sialic acids. It is a rate-limiting
enzyme in the sialic acid biosynthetic pathway. Sialic acid
modification of cell surface molecules is crucial for their
function in many biologic processes, including cell adhesion and
signal transduction. Differential sialylation of cell surface
molecules is also implicated in the tumorigenicity and metastatic
behavior of malignant cells. Mutations in this gene are associated
with sialuria, autosomal recessive inclusion body myopathy, and
Nonaka myopathy. Alternative splicing of this gene results in
transcript variants encoding different isoforms. [provided by
RefSeq].
- Stober, A., et al. Neuromuscul. Disord. 20(5):335-336(2010)
- Reinke, S.O., et al. Glycoconj. J. 26(4):415-422(2009)
- Tong, Y., et al. PLoS ONE(10), E7165 (2009) :
- Reinke, S.O., et al. FEBS Lett. 581(17):3327-3331(2007)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Hamster, Mouse, Rat
This GNE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 169-197 amino acids from the N-terminal region of human GNE.
10020
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
GNE
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
79 kDa
Q9Y223
45476991
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cell Cycle
Q9Y223
Optimal dilutions for each application to be determined by the researcher.