Further Information
Polyubiquitin-C, Ubiquitin, UBC
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
For IF starting dilution is: 1:10~50
This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome.
- Chan, Y.L., et al., Biochem. Biophys. Res. Commun. 215(2):682-690 (1995).
- Cook, W.J., et al., J. Mol. Biol. 236(2):601-609 (1994).
- Hubbard, M.J., et al., Biochim. Biophys. Acta 1200(2):191-196 (1994).
- Wajih, N., et al., Protein Seq. Data Anal. 5(1):31-32 (1992).
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Chicken, Yeast, Xenopus, Bovine, C. Elegans, Drosophila
This Ubiquitin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-66 amino acids of human Ubiquitin.
7316
Polyubiquitin-C
UBC
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
77 kDa
P0CG48
391358178
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Cell Cycle,Neuroscience
P0CG48
Optimal dilutions for each application to be determined by the researcher.