Further Information
Nuclease-sensitive element-binding protein 1, CCAAT-binding transcription factor I subunit A, CBF-A, DNA-binding protein B, DBPB, Enhancer factor I subunit A, EFI-A, Y-box transcription factor, Y-box-binding protein 1, YB-1, YBX1, NSEP1, YB1
For WB starting dilution is: 1:1000
For IF starting dilution is: 1:10~50
YBX1 binds to splice sites in pre-mRNA and regulates splice site selection. This protein binds and stabilizes cytoplasmic mRNA and contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors. It binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as HLA class II genes. It regulates the transcription of numerous genes and promotes separation of DNA strands that contain mismatches or are modified by cisplatin. It has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro), and it may play a role in DNA repair.
- Fujii,T., Cancer Res. 68 (5), 1504-1512 (2008)
- Fraser,D.J., Kidney Int. 73 (6), 724-732 (2008)
- Shiota,M., Cancer Res. 68 (1), 98-105 (2008)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Xenopus, Bovine, Mouse, Rat
This YBX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 276-305 amino acids from the C-terminal region of human YBX1.
4904
Nuclease-sensitive element-binding protein 1
YBX1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
36 kDa
P67809
54040031
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Cell Cycle,Signal Transduction
P67809
Optimal dilutions for each application to be determined by the researcher.