Further Information
Low affinity immunoglobulin gamma Fc region receptor III-A, CD16a antigen, Fc-gamma RIII-alpha, Fc-gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcR-10, IgG Fc receptor III-2, CD16a, FCGR3A, CD16A, FCG3, FCGR3, IGFR3
For WB starting dilution is: 1:1000
This gene encodes a receptor for the Fc portion of
immunoglobulin G, and it is involved in the removal of
antigen-antibody complexes from the circulation, as well as other
other antibody-dependent responses. This gene (FCGR3A) is highly
similar to another nearby gene (FCGR3B) located on chromosome 1.
The receptor encoded by this gene is expressed on natural killer
(NK) cells as an integral membrane glycoprotein anchored through a
transmembrane peptide, whereas FCGR3B is expressed on
polymorphonuclear neutrophils (PMN) where the receptor is anchored
through a phosphatidylinositol (PI) linkage. Mutations in this gene
have been linked to susceptibility to recurrent viral infections,
susceptibility to systemic lupus erythematosus, and alloimmune
neonatal neutropenia. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene.
- Dornan, D., et al. Blood 116(20):4212-4222(2010)
- Li, S.C., et al. Am. J. Hematol. 85(10):810-812(2010)
- Iwasaki, M., et al. Breast Cancer Res. Treat. (2010) In press :
- Qu, Y.H., et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi 18(4):959-962(2010)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This FCGR3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 226-254 amino acids from the C-terminal region of human FCGR3A.
2214
Low affinity immunoglobulin gamma Fc region receptor III-A
FCGR3A
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
29 kDa
P08637
119876
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunology,Signal Transduction
P08637
Optimal dilutions for each application to be determined by the researcher.