Further Information
FXYD domain-containing ion transport regulator 5, Dysadherin, FXYD5, DYSAD, IWU1
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
This gene encodes a member of a family of small membrane
proteins that share a 35-amino acid signature sequence domain,
beginning with the sequence PFXYD and containing 7 invariant and 6
highly conserved amino acids. The approved human gene nomenclature
for the family is FXYD-domain containing ion transport regulator.
Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2,
also known as the gamma subunit of the Na,K-ATPase, regulates the
properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma),
FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to
induce channel activity in experimental expression systems.
Transmembrane topology has been established for two family members
(FXYD1 and FXYD2), with the N-terminus extracellular and the
C-terminus on the cytoplasmic side of the membrane. This gene
product, FXYD5, is a glycoprotein that functions in the
up-regulation of chemokine production, and it is involved in the
reduction of cell adhesion via its ability to down-regulate
E-cadherin. It also promotes metastasis, and has been linked to a
variety of cancers. Alternative splicing results in multiple
transcript variants. [RefSeq curation by Kathleen J. Sweadner,
Ph.D., sweadner@helix.mgh.harvard.edu.].
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Ono, K., et al. Anticancer Res. 30(9):3273-3278(2010)
- Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
- Liang, J.F., et al. Pathol. Res. Pract. 205(7):445-450(2009)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This FXYD5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-100 amino acids from the Central region of human FXYD5.
53827
FXYD domain-containing ion transport regulator 5
FXYD5
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
19 kDa
Q96DB9
311033386
This antibody is purified through a protein A column, followed by peptide affinity purification.
Signal Transduction
Q96DB9
Optimal dilutions for each application to be determined by the researcher.