ProSci

SF3B4 Antibody

Product Code:
 
PSI-60-518
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in Hela cell line lysates (35ug/lane).
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Western blot analysis in Hela cell line lysates (35ug/lane).

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PSI-60-518-400ul400ul£626.00
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Further Information

Additional Names:
Splicing factor 3B subunit 4, Pre-mRNA-splicing factor SF3b 49 kDa subunit, SF3b50, Spliceosome-associated protein 49, SAP 49, SF3B4, SAP49
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly to pre-mRNA.
Background References:
  • Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)
  • Rikova, K., et al. Cell 131(6):1190-1203(2007)
  • Watanabe, H., et al. J. Biol. Chem. 282(28):20728-20738(2007)
  • Wu, C., et al. Proteomics 7(11):1775-1785(2007)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Immunogen:
This SF3B4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 158-187 amino acids from the Central region of human SF3B4.
NCBI Gene ID #:
10262
NCBI Official Name:
Splicing factor 3B subunit 4
NCBI Official Symbol:
SF3B4
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
44 kDa
Protein Accession #:
Q15427
Protein GI Number:
2500587
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q15427
User NOte:
Optimal dilutions for each application to be determined by the researcher.