Further Information
Hydroperoxide isomerase ALOXE3, Epidermis-type lipoxygenase 3, Epidermal LOX-3, e-LOX-3, eLOX-3, Hydroperoxy icosatetraenoate dehydratase, ALOXE3
For WB starting dilution is: 1:1000
ALOXE3 is a member of the lipoxygenase family, which
are catabolized by arachidonic acid-derived compounds. The encoded
enzyme is a hydroperoxide isomerase that synthesizes a unique type
of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic
acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This
epoxy alcohol can activate the the nuclear receptor peroxisome
proliferator-activated receptor alpha (PPARalpha), which is
implicated in epidermal differentiation. Loss of function of the
enzyme encoded by this gene results in ichthyosis, implicating the
function of this gene in the differentiation of human skin.
- Han, S., et al. Hum. Immunol. 71(7):727-730(2010)
- Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)
- Vahlquist, A., et al. J. Invest. Dermatol. 130(2):438-443(2010)
- Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 18(5):1651-1658(2009)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This ALOXE3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 223-252 amino acids from the Central region of human ALOXE3.
59344
Hydroperoxide isomerase ALOXE3
ALOXE3
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
81 kDa
Q9BYJ1
27923803
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cell Cycle,Obesity,Signal Transduction
Q9BYJ1
Optimal dilutions for each application to be determined by the researcher.