Further Information
Neural cell adhesion molecule L1, N-CAM-L1, NCAM-L1, CD171, L1CAM, CAML1, MIC5
For WB starting dilution is: 1:1000
L1CAM is an axonal glycoprotein
belonging to the immunoglobulin supergene family. The ectodomain,
consisting of several immunoglobulin-like domains and
fibronectin-like repeats (type III), is linked via a single
transmembrane sequence to a conserved cytoplasmic domain. This cell
adhesion molecule plays an important role in nervous system
development, including neuronal migration and differentiation.
Mutations in the gene cause three X-linked neurological syndromes
known by the acronym CRASH (corpus callosum hypoplasia,
retardation, aphasia, spastic paraplegia and hydrocephalus).
Alternative splicing of a neuron-specific exon is thought to be
functionally relevant.
- Schafer, M.K., et al. FEBS Lett. 584(21):4475-4480(2010)
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Bertolin, C., et al. J. Neurol. Sci. 294 (1-2), 124-126 (2010) :
- Schafer, M.K., et al. Cell. Mol. Life Sci. 67(14):2425-2437(2010)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Rat
This L1CAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1154-1182 amino acids from the C-terminal region of human L1CAM.
3897
Neural cell adhesion molecule L1
L1CAM
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
140 kDa
P32004
1705571
This antibody is purified through a protein A column, followed by peptide affinity purification.
Neuroscience,Signal Transduction
P32004
Optimal dilutions for each application to be determined by the researcher.