Antibody Isotype:
Rabbit Ig
Antibody Clonality:
Polyclonal
Applications:- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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This product comes from:
United States.
Typical lead time:
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- Further Information
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Further Information
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, PI3K-C2-alpha, PtdIns-3-kinase C2 subunit alpha, Phosphoinositide 3-kinase-C2-alpha, PIK3C2A
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
The protein encoded by this gene belongs to the
phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in
signaling pathways involved in cell proliferation, oncogenic
transformation, cell survival, cell migration, and intracellular
protein trafficking. This protein contains a lipid kinase catalytic
domain as well as a C-terminal C2 domain, a characteristic of class
II PI3-kinases. C2 domains act as calcium-dependent phospholipid
binding motifs that mediate translocation of proteins to membranes,
and may also mediate protein-protein interactions. The PI3-kinase
activity of this protein is not sensitive to nanomolar levels of
the inhibitor wortmanin. This protein was shown to be able to be
activated by insulin and may be involved in integrin-dependent
signaling.
- Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Kostakis, G.C., et al. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109 (5), E53-E58 (2010) :
- Koutros, S., et al. Cancer Res. 70(6):2389-2396(2010)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This PIK3C2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1431-1458 amino acids from the C-terminal region of human PIK3C2A.
5286
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
PIK3C2A
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
191 kDa
O00443
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunology,Signal Transduction
O00443
Optimal dilutions for each application to be determined by the researcher.