Further Information
Transcription factor AP-2-alpha, AP2-alpha, AP-2 transcription factor, Activating enhancer-binding protein 2-alpha, Activator protein 2, AP-2, Tfap2a, Ap2tf, Tcfap2a
For WB starting dilution is: 1:1000
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.
- Moser M.,et al.Nucleic Acids Res. 21:4844-4844(1993).
- Meier P.,et al.Dev. Biol. 169:1-14(1995).
- Carninci P.,et al.Science 309:1559-1563(2005).
- Mitchell P.J.,et al.Genes Dev. 5:105-119(1991).
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Bovine, Rat
This mouse Tfap2a antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 134-166 amino acids from the Central region of mouse Tfap2a.
21418
Transcription factor AP-2-alpha
Tfap2a
Mus musculus
Liquid
PREDICTED MOLECULAR WEIGHT:
48 kDa
P34056
This antibody is purified through a protein A column, followed by peptide affinity purification.
P34056
Optimal dilutions for each application to be determined by the researcher.