Sodium glycochenodeoxycholate
Product Code:
CDX-G0033
CDX-G0033
Regulatory Status:
RUO
RUO
Shipping:
Ambient
Ambient
Storage:
-20 °C
-20 °C
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| Code | Size | Price |
|---|
| CDX-G0033-M500 | 500 mg | £145.00 |
Quantity:
| CDX-G0033-G001 | 1 g | £248.00 |
Quantity:
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This product comes from: Switzerland.
Typical lead time: 7-10 working days.
Contact us for more accurate information.
Typical lead time: 7-10 working days.
Contact us for more accurate information.
- Further Information
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Further Information
Alternate Names/Synonyms:
Sodium glycochenodeoxycholate; GCDCA; NSC 681056; Chenylglycine sodium; N-(3alpha,7alpha-Dihydroxy-24-oxocholan-24-yl)glycine sodium salt
Appearance:
White to off-white powder.
CAS:
16564-43-5
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep cool and dry.Protect from light and moisture.
InChi:
InChI=1S/C26H43NO5.Na/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29;/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32);/q;+1/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-;/m1./s1
InChiKey:
AAYACJGHNRIFCT-YRJJIGPTSA-M
Long Description:
Chemical. CAS: 16564-43-5. Formula: C26H42NNaO5. MW: 471.61. Synthetic. Glycochenodeoxycholic acid (GCDCA) is a bile salt formed in the liver that acts as a biosurfactant to solubilize lipids for absorption and is itself absorbed. GCDCA functions as a choleretic, increasing the volume of bile secreted from the liver, and a cholagogue, promoting the discharge of bile from the digestive system. GCDCA has been used to demonstrate a role for bile acids in promoting colorectal carcinogenesis and to inhibit calcium hydroxyapatite precipitation to study the pathogenesis of black pigment gallstones. This product has also been shown to induce apoptosis in isolated hepatocytes via modulation of PKC activity. This compound is used as an anionic detergent to solubilize lipids and as a chiral reagent.
MDL:
MFCD00003636
Molecular Formula:
C26H42NNaO5
Molecular Weight:
471.61
Package Type:
Vial
Product Description:
Glycochenodeoxycholic acid (GCDCA) is a bile salt formed in the liver that acts as a biosurfactant to solubilize lipids for absorption and is itself absorbed. GCDCA functions as a choleretic, increasing the volume of bile secreted from the liver, and a cholagogue, promoting the discharge of bile from the digestive system. GCDCA has been used to demonstrate a role for bile acids in promoting colorectal carcinogenesis and to inhibit calcium hydroxyapatite precipitation to study the pathogenesis of black pigment gallstones. This product has also been shown to induce apoptosis in isolated hepatocytes via modulation of PKC activity. This compound is used as an anionic detergent to solubilize lipids and as a chiral reagent.
Purity:
>97% (HPLC)
SMILES:
[H][C@]1([C@@H](CCC(NCC(O[Na])=O)=O)C)CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
Solubility Chemicals:
Slightly soluble in DMSO, ethanol or methanol (10mg/ml) and in water.
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
Documents
References
(1) S. Barnes, et al.; J. Lipid Res. 20, 952 (1979) | (2) S.M. Qiu, et al.; J. Clin. Invest. 88, 1265 (1991) | (3) B. Gonzalez, et al.; Mol. Cell. Biochem. 207, 19 (2000) | (4) M. Iwata, et al.; Hepatol. Res. 25, 329 (2003) | (5) S. Ishizuka, et al.; Biomed. Res. 33, 159 (2012)