NSJ Bioreagents

ADAM17 Antibody

Product Code:
 
NSJ-R30942
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application:
 
Western Blot (WB)
Storage:
 
After reconstitution, the ADAM17 antibody can be stored for up to one month at 40. For long-term, aliquot and store at -200. Avoid repeated freezing and thawing.
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Western blot testing of ADAM17 antibody and Lane 1: human placenta; 2: HeLa; 3: PANC; 4: 293T cell lysate. Expected size: 80-130KD depending on level of glycosylation
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Western blot testing of ADAM17 antibody and Lane 1: human placenta; 2: HeLa; 3: PANC; 4: 293T cell lysate. Expected size: 80-130KD depending on level of glycosylation

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NSJ-R30942-100ug100 ug£535.00
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Further Information

Application Details :
Western blot: 0.5-1ug/ml
Application Note:
The stated application concentrations are suggested starting amounts. Titration of the ADAM17 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
ADAM metallopeptidase domain 17, also called TACE (Tumor necrosis factor-alpha-converting enzyme), is an enzyme that belongs to the ADAM proteinfamily of disintegrins and metalloproteases. Expression studies showed that the encoded protein cleaves precursor tumor necrosis factor-alpha to its mature form. Northern blot analysis revealed that the gene was expressed as a 5-kb mRNA in all tissues examined. ADAM17 is understood to be involved in the processing of tumor necrosis factor alpha (TNF-alpha) at the surface of the cell, and from within theintracellular membranesof the trans-Golgi network. This process, which is also known as shedding, involves the cleavage and release of a soluble ectodomain from membrane-bound pro-proteins (such as pro-TNF-alpha), and is of known physiological importance. ADAM17 was the first sheddase to be identified, and is also understood to play a role in the release of a diverse variety of membrane-anchored cytokines, cell adhesion molecules, receptors, ligands, and enzymes.
Format :
Antigen affinity purified
Formulation :
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Immunogen:
An amino acid sequence from the C-terminus of human ADAM17 (AASFKLQRQNRVDSKETEC) was used as the immunogen for this ADAM17 antibody.
Limitation:
This ADAM17 antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Human, Mouse, Rat
Uniprot #:
P78536