CD1d is a membrane protein non-covalently bonded to β2-microglobulin (β2m) and shows high homology between human and mouse. CD1d can present α-galactosylceramide (α-GalCer), a glycolipid extracted and isolated from the marine sponge, and this complex can activate human and murine
The Use of Immunotherapy in Treating HHV-6 Infection
Human herpesvirus 6 (HHV-6) is a virus that exists as 2 species, HHV-6A and HHV-6B. HHV-6B, the more widespread species, is a pathogen infecting more than 90% of individuals world-wide during childhood and then establishing a latent and lifelong infection.
Tips for Staining Rare Antigens with MHC Tetramers
When performing staining with MHC tetramers, there may be certain cases where the staining is unclear. An example could be in certain cases where an antigen-specific T cell population of interest has a low frequency. The following tips discussed in
White Paper: Analysis of neoantigen-reactive T cells using the QuickSwitch™ custom tetramer kit
Kazuhiro Kakimi MD, PhD has been a leader in developing effective immunotherapies against cancer for the last 15 years in Japan. In this whitepaper, he and his colleagues have reported that the QuickSwitch™ Custom Tetramers will become an essential tool
Evaluating the biological activity of a cancer vaccine with the HLA-A*02:01 QuickSwitch™ Quant platform
Principle of the cell-based T2 shift assay and the cell-free QuickSwitch™ Quant assay Comparison of the cell-based T2 shift assay and the cell-free QuickSwitch™ Quant assay Immuno-oncology is a growing field in which different strategies such as immune modulators, vaccines
Non-classical MHC
Non-classical MHC: HLA-E and Qa-1b Human leukocyte antigen E (HLA-E) is a non-classical class I molecule recognised by natural killer (NK) cells and CD8+ T cells. HLA-E is expressed in almost all tissues including lung, liver, skin and placental cells. HLA-E expression
High-Quality Stock and Custom Peptides
Suitable for Stimulation Assays High-Quality Control ≥95% Purity and Mass Spec Analysed Custom tetramer generation using QuickSwitch™ and QuickSwitch™ Quant Tetramer MBL International‘s stock and custom peptides can be used for stimulation assays along with custom tetramer generation using
QuickSwitch™ – Quickly Create Custom Tetramers
Fast, High-Quality Generation of New Tetramer Specificities Rapid, high-quality creation of custom class I tetramers is now a reality! Create new specificity tetramers in just a few hours with QuickSwitch™ from MBL International; a proprietary technology for exchanging peptides on
Help! My mouse tetramer stained ALL the CD8+ T cells!
You’re sitting at your flow cytometer, staring at your CD8 x tetramer plot in anticipation of a tiny but meaningful group of dots appearing in the upper right quadrant. You hold your breath, click “acquire,” and watch… Wait, what? What’s