CD1d molecules are non-classical MHC molecules that present phospholipid and glycosphingolipid antigens to invariant Natural Killer T (iNKT) cells. This axis is involved in the regulation of nearly all aspects of innate and acquired immune responses.
CD1d is widely researched for its role and therapeutic potential in many disease indications. These include schistosomiasis, glioblastoma, multiple myeloma, systemic lupus erythematosus and viral infections – which are responsible for severe clinical outcomes worldwide.
MBL International offers CD1d tetramers prepared by tetramerisation of complexes of CD1d and β2m by PE- or APC- labelled streptavidin. Binding this reagent to α-GalCer enables highly-sensitive detection of CD1d-restricted NKT cells and can be combined with antibodies to study NKT cell function through flow cytometry. α-GalCer loaded tetramers are also available.
| Product Code | Product Name | |
| TS-MCD-1 | Mouse CD1d Tetramer-SA | PE |
| TS-MCG-1 | Mouse CD1d Tetramer (α-GalCer loaded) | PE |
| TS-HCD-1 | Human CD1d Tetramer | PE |
| TS-HCG-1 | Human CD1d Tetramer (α-GalCer loaded) | PE |
REFERENCES:
- Hojo MAet al. Identification of a genomic enhancer that enforces proper apoptosis induction in thymic negative selection. Nat Commun. 10, 2603 (2019)(PMID:31197149)
- Shimizu K et al. Eomes transcription factor is required for the development and differentiation of invariant NKT cells. Commun Biol. 2, 150 (2019) (PMID:31044175)
- Komine-Aizawa S et al. Cow milk exosomes activate NK cells and γδT cells in human PBMCs in vitro. Immunol Med. 43, 161-170 (2020)(PMID:32649844)
Information provided by MBL International.
Caltag Medsystems is the distributor of MBL International products in the UK and Ireland. If you have any questions about these products, please contact us.