The CircuLex Human DJ-1/PARK7 ELISA Kit has been developed to measure the concentration of human DJ-1/PARK7 from human serum, plasma, cell lines and conditioned media.
DJ-1 (PARK7/CAP1/RS) is expressed in many cells and tissues, including the brain. Over-expression of DJ-1 can lead to cancer, whereas a loss of function can lead to neurodegenerative diseases, such as Parkinson’s Disease. DJ-1 has a protective role against the oxidative stress response, which is known to be involved in the pathogenesis in Parkinson’s Disease. Furthermore, DJ-1 has also been shown to have a protective role against the aggregation of α-synuclein, a major component in Lewy Bodies present in neurons of patients with Parkinson’s Disease. More recently, DJ-1 is has been considered as a potential biomarker in the detection of early stage cerebral infarction since it’s concentration increases three hours after cerebral injury.
The CircuLex Human DJ-1/PARK7 ELISA Kit is a quantitative sandwich ELISA specific for human DJ-1. The Human DJ-1 ELISA Kit has a high sensitivity to detect human DJ-1, with an LOD of 8.4pg/mL.
Product Information
CircuLex Human DJ-1/PARK7 ELISA Kit – for the Detection of Human DJ-1
Product Code: CY-9050V2
Caltag Medsystems is the distributor of MBLI’s products in the UK and Ireland. If you have any questions about these products, please contact us.
References for the Detection of Human DJ-1 using the CircuLex Human DJ-1/PARK7 ELISA:
Bande MF, Santiago M, Blanco MJ, Mera P, Capeans C, Rodr_guez-Alvarez MX, Pardo M, Pieiro A. (2012). Serum DJ-1/PARK 7 Is a Potential Biomarker of Choroidal Nevi Transformation. Investigative Ophthalmology & Visual Science 53: 62-7.
An CN, Jiang H, Wang Q, Yuan RP, Liu JM, Shi WL, Zhang ZY, Pu XP (2011). Down-regulation of DJ-1 protein in the ejaculated spermatozoa from Chinese asthenozoospermia patients. Fertility and Sterility 96: 19-23
Satoshi Yamashita, Akira Mori, En Kimura, Shuji Mita, Yasushi Maeda, Teruyuki Hirano, Makoto Uchino (2010). DJ-1 forms complexes with mutant SOD1 and ameliorates its toxicity. Journal of Neurochemistry 113: 860-870
If you would like further information on the CircuLex Human DJ-1/PARK7 ELISA Kit for the detection of Human DJ-1, including the full list of references, please contact office@caltagmedsystems.co.uk