GITR – GITRL Pathway

GITR – GITRL Pathway

Glucocorticoid-induced TNFR-related protein (GITR; CD357; TNFRSF18) is an activating receptor on the surface of T cells and other immune cells, binding to its ligand GITRL (TNFSF18). Once exposure to tumour antigen activates a T cell, the number of GITR receptors on its surface increases. On the activated T cell, GITR acts as a co-stimulatory receptor, meaning that it is a receptor whose signalling enhances cell reproduction and the generation of cancer-killing activity. Activation of GITR signalling can also help to enhance immunity through the activation of cytotoxic T cells and inhibition of Treg activity.

LIT:  Modulation of GITR for cancer immunotherapy: D.A. Schaer, et al.; Curr. Opin. Immunol. 24, 217 (2012) | Rationale for anti-GITR cancer immunotherapy: D.A. Knee, et al.; Eur. J. Cancer 67, 1 (2016)

Biologically Active GITR and GITRL Proteins 

See all Biologically Active GITR and GITRL Proteins by AdipoGen Life Sciences here.

See all Biologically Active GITR and GITRL Proteins by Chimerigen here.

VALIDATED Antibodies for GITR and GITRL Research

See all VALIDATED Antibodies for GITR and GITRL Research by AdipoGen Life Sciences here.

See all VALIDATED Antibodies for GITR and GITRL Research by Ancell here.

Originally posted on adipogen.com/gitr-gitrl-pathway/

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GITR – GITRL Pathway
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