Glucocorticoid-induced TNFR-related protein (GITR; CD357; TNFRSF18) is an activating receptor on the surface of T cells and other immune cells, binding to its ligand GITRL (TNFSF18). Once exposure to tumour antigen activates a T cell, the number of GITR receptors on its surface increases. On the activated T cell, GITR acts as a co-stimulatory receptor, meaning that it is a receptor whose signalling enhances cell reproduction and the generation of cancer-killing activity. Activation of GITR signalling can also help to enhance immunity through the activation of cytotoxic T cells and inhibition of Treg activity.
LIT: Modulation of GITR for cancer immunotherapy: D.A. Schaer, et al.; Curr. Opin. Immunol. 24, 217 (2012) | Rationale for anti-GITR cancer immunotherapy: D.A. Knee, et al.; Eur. J. Cancer 67, 1 (2016)
Biologically Active GITR and GITRL Proteins
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VALIDATED Antibodies for GITR and GITRL Research
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Originally posted on adipogen.com/gitr-gitrl-pathway/
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