Integrins are heterodimeric cell surface receptors involved in cell-extracellular matrix and cell-cell adhesion. In addition, integrins convey two-way signalling between cells and their surroundings and participate in the regulation of a variety of cellular processes, including cell proliferation, migration, survival, tissue invasion, and innate immunity. Mammalian cells have 18 distinct integrin α subunits and 8 β subunits, which can combine in various ways to form 24 different receptor heterodimers. Integrin αvβ6 is expressed exclusively by epithelial cells and functions as a receptor for extracellular matrix proteins such as fibronectin. Furthermore, integrin αvβ6 expressed in the intestinal epithelium is involved in the suppression of inflammation and prevention of pathogen and parasite infection [1]. Anti-integrin αvβ6 antibodies have been detected in the vast majority of patients with ulcerative colitis, and its titers have been reported to correlate with disease activity [2].
For more information about the discovery of this kit, please read this article featuring Dr. Shiokawa and Dr. Kuwada.
MBLI is proud to introduce the Anti-Integrin αvβ6 ELISA Kit that readily allows measurement of anti-integrin αvβ6 antibody levels in human serum.
| Product Code | Product Name |
| 5288 | Anti-Integrin αvβ6 ELISA Kit |
REFERENCES:
1. Koivisto L, Bi J, Häkkinen L, Larjava H. Integrin αvβ6: Structure, function and role in health and disease. Int J Biochem Cell Biol. 2018 Jun;99:186-196. doi: 10.1016/j.biocel.2018.04.013. Epub 2018 Apr 18. PMID: 29678785.
2. Kuwada T, et al. Identification of an Anti-Integrin αvβ6 Autoantibody in Patients With Ulcerative Colitis. Gastroenterology. 2021 Jun;160(7):2383-2394.e21. doi: 10.1053/j.gastro.2021.02.019. Epub 2021 Feb 12. PMID: 33582126.
Information received from MBL International.
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