OX40 (CD134; TNFRSF4) is an activating receptor expressed on the surface of activated cytotoxic T cells and regulatory T cells (Tregs). OX40 plays a dual role in the immune response, both activating and amplifying T cell responses. On cytotoxic T cells, OX40 binds to its ligand OX40L (CD252; TNFSF4), resulting in stimulatory signals that promote T cell reproduction, function and survival. OX40/OX40L signalling blocks the ability of Tregs to suppress T cells and reduces Treg generation. By inhibiting the immunosuppressive effect of Tregs and limiting their population, OX40 further amplifies the impact of T cell activation. The dual effects of OX40 help to create a tumour microenvironment that is more favourable to the antitumour immune response.
LIT: OX40: Structure and function – What questions remain? J. Willoughby, et al.; Mol. Immunol. 83, 13 (2017) • The immunobiology of CD27 and OX40 and their potential as targets for cancer immunotherapy: S.L. Buchan, et al.; Blood 131, 39 (2018)
Biologically Active OX40 and OX40L Proteins
See all Biologically Active OX40 and OX40L Proteins by AdipoGen Life Sciences here.
See all Biologically Active OX40 and OX40L Proteins by Chimerigen here.
VALIDATED Antibodies for OX40 and OX40L Research
See all VALIDATED Antibodies for OX40 and OX40L Research by AdipoGen Life Sciences here.
See all VALIDATED Antibodies for OX40 and OX40L Research by Ancell here.
Originally posted on adipogen.com/ox40-ox40l-pathway/
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