TCRs recognize and bind to complexes composed of MHC molecules and specific peptides expressed on the surface of antigen-presenting cells. While it was once believed that antigen-specific T cells could be detected using soluble MHC/peptide complexes, monomeric MHC/peptide complexes proved
CML Green Initiative: Where to start…
When someone mentions that we should be doing more to save the planet, it is often met with a groan (do I really have to separate my food waste?). In a commercial setting, it can be hard to gain momentum
Innovative Applications of TransFix®
TransFix® is designed for stabilisation of peripheral blood and cerebrospinal fluid to enumerate lymphocyte subpopulations by flow cytometry. However, researchers have developed many new and innovative uses of TransFix. We’ve presented a selection of publications to highlight the versatility of
Curing Cancer with Magnetic Nanoparticles
Nanomedicine Scientists at Nanoprobes, Inc. are heralding a major breakthrough in cancer research, using their new magnetic nanoparticles. After a quick intravenous injection and just three minutes inside a magnetic field, 80% of their test animals are completely cured of
MHC Class I & II Tetramers, MHC Monomers and CD1d Tetramers
TCRs recognize and bind to complexes composed of MHC molecules and specific peptides expressed on the surface of antigen-presenting cells. We have tetramerized and biotinylated with streptavidin to maintain stable binding to multiple TCR, enabling MHC/peptide tetramers to be used
Monomers
Biotinylated MHC monomers, the building blocks of MHC tetramers, are now available for tetramer construction flexibility and novel applications. See All Monomer Products
CD1d
CD1d is a membrane protein non-covalently bonded to β2-microglobulin (β2m) and shows high homology between human and mouse. CD1d can present α-galactosylceramide (α-GalCer), a glycolipid extracted and isolated from the marine sponge, and this complex can activate human and murine
BeCytes Biotechnologies: Liver Cells for Research – Animal Hepatocytes
The Use of Immunotherapy in Treating HHV-6 Infection
Human herpesvirus 6 (HHV-6) is a virus that exists as 2 species, HHV-6A and HHV-6B. HHV-6B, the more widespread species, is a pathogen infecting more than 90% of individuals world-wide during childhood and then establishing a latent and lifelong infection.
BioAct – Cell Analysis Tools
A variety of cell studies including organelle detection and studies on function and proliferation of cells can be done using BioActs’ bright fluorescent probes and fluorescent antibodies. Since organelles have their own unique features, organelle-specific image tracking and analysis are