Green fluorescent protein (GFP) was first isolated by Dr. Osamu Shimomura in 1961. Since then, fluorescent protein (FP) technology has made drastic advancements by many researchers. Currently, FP technology is the most popular tool for visualizing target proteins. Dr. Shimomura,
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Mesenchymal Stem Cell Medium-animal component free (Cat. #7521) For decades, Fetal Bovine Serum (FBS) has been a vital supplement for the successful culture of a
13 Technical Tips for Successful Primary Cell Culture
When working with primary cells, it is important to remember that they are not cell lines and should be treated with care. At ScienCell, they specialise in primary cell culture and are very familiar with the common problems researchers encounter
Cancer Immunotherapy: A Colourful Past and A Bright Future
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ProSci Inc. offers an extensive range of antibodies and supporting tools to research Immune Checkpoints. Read more about their range below, or click a link to jump to a specific section: What Are Immune Checkpoints? What is Risk-Free™? Risk-Free™ Immune
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PD-L1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. PD-L1 can bind to PD-1, which mediates inhibitory signals from the APC. ProSci Inc. offers an extensive range
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After the development of Lipofection & MagnetofectionTM, OZ Biosciences revolutionises Polyfection with the design & synthesis of a patented CHAMP.
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The PD-1 protein is a negative co-stimulatory receptor that can bind two different but related ligands, PD-L1 and PD-L2. Upon binding, signals generated by PD-1 inhibit the activation of the immune response in the absence of “danger signals.” ProSci Inc.
Mechanisms and detection methods of p62/SQSTM1 and its importance in the autophagy pathway.
Mechanisms of Autophagy The ubiquitin-conjugating protein p62/SQSTM1 is thought to be a scaffold protein that interacts with a variety of molecules involved in toll-like receptor (TLR) signaling, such as TRAF6, ERK, and aPKC. Recent evidence suggests that p62 binds directly