The process of autophagy was first recognized in the late 1950s and it was thought of as bulk “junk” removal. Then, dedicated scientists did a little more digging and found there is an amazing methodology to the “junk” removal. It
Tools for Neurology Research
World Brain Day is annual initiative of the World Federation of Neurology. This year, on 22nd July, it was focused on Stroke prevention and treatment. In partnership with our global network of Life Science suppliers, we are pleased to bring
Why pure exosome isolation matters
Exosomes are cell-derived vesicles originating from multi-vesicular bodies and found in biological fluids such as blood, saliva, urine, and breast milk. Sizes of these extracellular vesicles (EVs) range between 30-100 nm. Due to their capacity to transfer proteins, lipids and
Why NCP 3D cell culture method helps your experiments become more real
3D cell culture innovation ensures that time spent at the bench will correlate to in vivo environments, with possibilities to aid in future discoveries such as drug delivery into tumor cells or understanding tissue microenvironment. Typically, a researcher use a
How to detect functional PCSK9 quickly and easily
PCSK9 remains an important target in cholesterol research. One of the hurdles in this research area is determining which PSCK9 form is present and binding with LDLR. MBL’s new Human PCSK9 Functional Assay Kit is designed to detect active PSCK9
March 2017: The Antibody Update
Caffeine is an Indirect Anti-Inflammatory Drug Interleukin-1β production is regulated by inflammasomes, a very large protein complex commonly associated with inflammation and pyroptosis. As the human body ages and accumulates metabolites, the inflammasome interacts with them and is primed for
February 2017: The Antibody Update
Epidermal Levels of Staphylococcus Aureus Are Affected by a Peptide Produced by Other Skin Dwelling Bacteria Staphylococcus aureus is common to many of people’s ski n microbiome, and is generally harmless; however, in high population density the bacteria can lead to atopic
Problems with Immunotherapy
Pairs of proteins that act as T-cell co-signaling receptors are called immune checkpoints. These cell surface receptors can send positive or negative signals to T cells, instigating a response from the immune system to either stimulate the immune system against
January 2017: The Antibody Update
Mitigating the Reproducibility Crisis in Cancer Drug Research Reproducibility has been highlighted as one of the main problems when validating cancer research. Scientists with the The Reproducibility Project have opted to begin pragmatically reviewing the reproducibility of the research released
T-cell Activation: The Purpose of CD28, CTLA-4, and CD80/CD86
A Guide to CD28, CTLA-4, and CD80/CD86 Interaction and Signaling Immune checkpoint receptors like CD28 and CTLA-4 have been of great interest in the research of cancer immunotherapy. These receptors and their ligands are part of what regulates T-cell activation