During the 2016 State of the Union Address, President Obama called attention to a myriad of issues currently plaguing Americans. One of the many initiatives President Obama announced in response was a “moonshot” to cure cancer, referencing the flood of
February 2016: The Antibody Update
Check out ProSci’s February Antibody Update for the latest news in the industry – This month discusses the cancer moonshot project, an update on the Zika virus, and gravitational waves. The Cancer Moonshot Patrick Soon-Shiong, a billionaire entrepreneur of
The Antibody Basics Series: Table of Contents
Not too long ago, we published The 5 A’s of Antibodies infographic, which provides a brief explanation of all what goes into the process of generating custom antibodies against specific targets. Our next step is to begin providing summaries of
A Brief Introduction to PD-1 Antibodies and Immunotherapy
President Jimmy Carter’s cancer remission was wonderful news, but as some outlets [1] noted, it is important to understand that not all patients are responding as well to similar treatments, and that there is currently still no “cure” for cancer.
Tips for Understanding the Reproducibility Crisis
An article published by Nature earlier this year pointed out that researchers now have to worry about the reproducibility of production antibodies. The fact of the matter is that off-the-shelf antibodies from large distributors can be unreliable tools, often functioning
ProSci’s 5 A’s of Antibody Development Infographic
Antibody development is multi-faceted process that begins with the target to which you wish to develop antibodies against: the antigen. To elicit an immune response we must select the appropriate adjuvant to be mixed with the antigen for immunization. Which
Antibody Basics: Hybridoma
Hybridoma Development Hybridoma technology is the core technique used to develop monoclonal antibodies at ProSci. A hybridoma is a single cell that consists of a cancerous myeloma cell and an immune B-cell which have been fused together into a single
Antibody Basics: Monoclonal, Polyclonal, and Recombinant Antibodies
While simple in principle, antibodies are deceivingly complex in structure and production. Do you know the advantages and disadvantages of monoclonal, polyclonal and recombinant antibody production? Let ProSci be your expert. Polyclonal → Monoclonal → Recombinant Polyclonal Antibodies: Polyclonal antibodies are characterized
Antibodies & Targets: An Introduction to SAMHD1
SAMHD1, or Sterile Alpha Motif and Histidine/Aspartate domain-containing protein 1, is a dimeric enzyme with phosphohydrolase and nuclease activity that functions as a blockade for virus replication in dendritic cells, monocytes, and macrophages. Its activity is regulated through phosphorylation of
Searching for the Heart of the Problem: Antibodies to Cardiac Myosin Binding Protein
ProSci works with Dr. Sadayappan to create a set of custom antibodies used to study cardiomyopathy. Cardiac Myosin Binding Protein-C (cMyBP-C) is a protein present in cardiac muscle that has been shown to affect the organizational structure of the muscle