Drug metabolism and clearance HepaRG™ cells are classified as an “average human hepatocyte population” and express multiple functional Phase 1 and 2 drug metabolising enzyme (DME) activities comparable to levels in cultures of primary human hepatocytes. This makes them a
Small Molecules: Product Highlights
Caltag Medsystems have a vast portfolio of compounds for research – including inhibitors, biochemicals, small molecules, lipids and antibiotics. To view our full range of compounds, please click here. Alternatively, if you know what you are looking for, you can
Silensomes: One single model for DMPK phenotyping studies
Silensomes™ are human pooled liver microsomes in which one specific CYP has been chemically knocked out and are capable of directly quantifying and predicting the contribution of CYP enzymes in drug metabolism. Until now, a battery of in-vitro tests recommended by the regulatory
Request a Cell Culture Booklet
Caltag Medsystems: Your Cell Culture Provider Our Cell Culture portfolio ranges from primary cells, stem cells, cell lines and media to skin, fresh animal brains, healthy & diseased products, angiogenesis models and transfection reagents. We have put together a booklet to provide
Stem Cell Basics
Stem cells, by definition, can undergo infinite number of cell division while remain in an undifferentiated state. However, stem cells can also give rise to differentiated daughter cells that are committed to specialised cell fate in all three primary germ
Human Renal Proximal Tubular Epithelial Cells (HRPTEpiC)
Renal proximal tubular epithelial cells (PTEpiC) play a crucial role in renal function. They reabsorb nearly all of the glucose and amino acids in the glomerular filtrate, while allowing other substances of no nutritional value to be excreted in the
Human Hepatic Stellate Cells
ScienCell’s Human Hepatic Stellate Cells (Product Code: SC-5300) cultured in Stellate Cell Medium (Product Code: SC-5301) is an optimal model for many research areas including liver injury, hepatic development, regeneration, xenobiotic responses, intermediary metabolism, and immunoregulation. Studying HHSteC will lead
Microtubules and the Assembly of the Inflammasome Complex
Inflammasomes are assembled from a pattern-recognition receptor, the adapter protein Asc and caspase-1 to process interleukin-1b (IL-1b) and IL-18 in response to microbial components or damage-associated signals. Recently, it was shown that microtubules might have a central role in the
Inflammasome Signalling
Inflammasomes are multi-protein complexes whose activity has been implicated in physiological and pathological inflammation. The hallmarks of inflammasome activation are the secretion of the mature forms of caspase-1 and interleukin-1β (IL-1β) from cells of the innate immune system. AdipoGen provides
The HitAlert Kit: A complete kit for the reliable diagnosis of Heparin-Induced Thrombocytopenia
The HITAlert Kit™ is a CE/IVD functional assay for the diagnosis of Heparin Induced Thrombocytopenia. This kit uses donor platelets (PRP) which are incubated in the presence of patient serum and in the presence or absence of heparin. A platelet activation marker