The S100 protein family, which comprises 20 members, consists of calcium-binding proteins with two unique helix-loop-helix motifs (EF-hands). These proteins exhibit cell type-specific expression, showcasing their versatility in various cellular pathways. Renowned for their involvement in diverse cellular pathways and diseases, S100 proteins play a pivotal role in the intricate workings of our cells.
Certain S100 proteins engage with targets inside our cells, demonstrating their versatile nature. S100A6, for instance, forms a connection with p53 in the cytosol, effectively regulating apoptosis. On the other hand, different S100 proteins interact with targets outside the cell, whether it be binding to extracellular receptors or attaching to circulating proteins in the extracellular environment. The significance of S100 proteins expands beyond these interactions, encompassing crucial cellular processes including apoptosis, inflammation, energy metabolism, and proliferation. Remarkably, these proteins have also been implicated in various types of cancer, highlighting their involvement in the intricate workings of our biology.
MBL International offers a variety of S100 ELISA kits.
The CircuLex S100 Protein Detection kit series are designed to measure the concentration of S100 protein family from serum, plasma and other biological media.
| Product Code | Product Name |
| CY-8061 | CircuLex S100A8/MRP8 ELISA Kit |
| CY-8062 | CircuLex S100A9/MRP14 ELISA Kit |
| CY-8063 | CircuLex S100A11 ELISA Kit |
| CY-8095 | CircuLex S100A10 ELISA Kit |
| CY-8058V2 | CircuLex S100A12/EN-RAGE ELISA Kit Ver.2 |
Product Citations
CY-8062:
Ward, Grace Anne. Defining the Role of Oxidized Mitochondrial DNA in Myelodysplastic Syndromes. Diss. University of South Florida, 2022.
Ward, Grace A., et al. “Oxidized mitochondrial DNA released after inflammasome activation is a disease biomarker for myelodysplastic syndromes.” Blood advances 5.8 (2021): 2216-2228.
CY-8061:
Enomoto, Noriyuki, et al. “Frequency, proportion of PF-ILD, and prognostic factors in patients with acute exacerbation of ILD related to systemic autoimmune diseases.” BMC Pulmonary Medicine 22.1 (2022): 387.
Tanaka, Kazuki, et al. “Serum S100A8 and S100A9 as prognostic biomarkers in acute exacerbation of idiopathic pulmonary fibrosis.” Respiratory Investigation 59.6 (2021): 827-836.
CY-8058V2:
Balog, Attila, et al. “Kynurenic Acid Analog Attenuates the Production of Tumor Necrosis Factor-α, Calgranulins (S100A 8/9 and S100A 12), and the Secretion of HNP1–3 and Stimulates the Production of Tumor Necrosis Factor-Stimulated Gene-6 in Whole Blood Cultures of Patients with Rheumatoid Arthritis.” Frontiers in Immunology 12 (2021): 632513.
Information provided by MBL International.
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