The mammalian homologue of Atg8, LC3, is the most actively studied and frequently used as a mammalian autophagy marker.
LC3
Atg12 Binding Cascade: Cross-talk Between Apoptosis and Autophagy
MBLI’s autophagy reagents include important targets such as LC3, p62/SQSTM1, ATG12, ATG14, ATG16L, ATG9, ULK1, and more.
White Paper: Role of the autophagy regulator Rubicon in the pathogenesis of fatty liver disease
In 2016, Dr. Tanaka, Dr. Yoshimori, and their colleagues clarified that increased expression of Rubicon in liver causes fatty liver. This was the first report to demonstrate fatty liver is caused by suppression of autophagy in an acquired environment. In this
Mechanisms and detection methods of p62/SQSTM1 and its importance in the autophagy pathway.
Mechanisms of Autophagy The ubiquitin-conjugating protein p62/SQSTM1 is thought to be a scaffold protein that interacts with a variety of molecules involved in toll-like receptor (TLR) signaling, such as TRAF6, ERK, and aPKC. Recent evidence suggests that p62 binds directly
Why Autophagy research won a Nobel Prize
The process of autophagy was first recognized in the late 1950s and it was thought of as bulk “junk” removal. Then, dedicated scientists did a little more digging and found there is an amazing methodology to the “junk” removal. It
October 2016: The Antibody Update
The Nobel Prize in Medicine was Awarded to Yoshinori Ohsumi for His Work on Autophagy Autophagy is the cellular process that regulates a cells ability to degrade parts of itself that must be replaced. Yoshinori Ohsumi’s work in autophagy has proven to
The ABC’s of LC3
What are LC3 isoforms all about? What do they do? How are they different? How are they involved in autophagy? Autophagy is a pretty important cellular process. It allows a cell to survive a state of starvation. What this means
Autophagy Watch
What does autophagy flux mean? You have come to the right place to learn a little more about autophagy flux and how MBL International’s Autophagy Watch kit can help you. Autophagy allows for cell survival during subprime conditions, such as nutrient
The Ubiquitin-Proteasome System
The UPS and the autophagic-lysosomal pathway are the two major degradation systems for native & misfolded proteins in eukaryotic cells.