Diaclone have developed a series of high-quality recombinant proteins, for research into Human SARS-CoV-2 and immune responses. Diaclone’s proteins are suitable for a wide range of applications, including cell culture, immunoassays, bioassays and more. These proteins are now available in
Interleukin-6 release in response to Coronavirus 19
Coronavirus 19 is known to infect the respiratory tract and cause mild or highly acute respiratory syndrome. A consequence of this is the release of pro-inflammatory cytokines, including interleukin (IL)-1β and IL-6 (1). This hyperinflammatory response is thought to be
The Dark Side of CAR-T Therapy – Cytokine Release Syndrome (Diaclone)
Immunotherapies such as monoclonal antibodies, bispecific antibodies (Bi-specific T-cell engagers or BiTEs) and adoptive T-cell therapies (e.g. CAR-modified T-cell) have provided great advances in cancer treatment. However, testing new therapies is not without risk. The most common and potentially severe
What’s New at Diaclone?
The Diaclone name has stood for quality and reliability for 34 years. Based in Besançon, France, Diaclone pride themselves on excellence in monoclonal antibody and immunoassay development and manufacture. The expanding range of Diaclone immunology products is specifically designed to
What’s the KD of my Antibody?
Understanding binding affinity is an important part of the drug discovery process, ensuring that therapeutic antibodies that bind their targets selectively and specifically. It also helps to understand the intermolecular interactions driving biological processes, structural biology, and structure-function relationships. KD
Diaclone ELISpot: Ex-vivo Analysis of Protein Secretion
The Enzyme Linked Immunospot (ELISpot) Assay is a versatile and highly sensitive method for ex-vivo analysis of protein secretion post cell stimulation. Virtue of its high sensitivity (1 cell in 100,000) the ELISpot assay enables frequency analysis of activated cell
Diaclone Biologically Active Antibodies
Investigate your cellular assay systems using the Diaclone range of Biologically Active Monoclonal Antibodies. Diaclone offers a broad range of biologically active, Azide Free antibodies suitable for induction, activation, neutralisation and inhibition studies. Available Biologically Active Antibodies Diaclone products are
Diaclone DIAplex
Diaclone DIAplex is a sensitive multiplex fluorescent bead-based immunoassay for the simultaneous quantification of multiple analytes from a single sample by flow cytometry. Utilising bead populations with distinct fluorescence intensities and unique antibody specificities, Diaclone DIAplex can accurately measure multiple
CD138 (Syndecan-1) Detection
CD138 is a member of the trans-membrane heparin sulphate proteoglycan family involved in many cellular functions including cell proliferation, cell migration, cell signalling, cytoskeletal organisation and mediates both cell-cell and cell-extracellular matrix interactions. Additionally, via its heparin sulphate chains, it
Measure Immune Response & Treatment Efficacy with Diaclone ELISpot Kits
Monitoring the immune responses of patients treated with immunotherapy is essential to evaluate the efficacy of treatment and correlate clinical responses to Cytotoxic T Lymphocyte responses. Diaclone ELISPot assays are specific, accurate, sensitive, precise & robust. This bioassay is recognised