In a previous blog post (How to screen SARS-CoV-2 peptides to facilitate T cell research) MBL International described how the immune system samples all of the pathogenic proteins by looking at the small fragments of each protein and determining whether
How to screen SARS-CoV-2 peptides to facilitate T cell research
Whenever our immune system is faced with a challenge, be it a multicellular parasite, a bacteria, a virus, or even cancer, this threat is detected and sampled primarily by the protein sequence of the pathogen in question. Other aspects of
Revel the Mechanisms of Host Defense by Cross-regulation of Toll-like Receptor (TLR) Responses
A recent Nature Immunology paper describes the epigenetic landscape that results from the integration of the inflammatory cytokines type I interferons and TNF. This comprehensive epigenomics approach to the analysis of human macrophages showed that the proinflammatory cytokines TNF and type
Measure Immune Response & Treatment Efficacy with Diaclone ELISpot Kits
Monitoring the immune responses of patients treated with immunotherapy is essential to evaluate the efficacy of treatment and correlate clinical responses to Cytotoxic T Lymphocyte responses. Diaclone ELISPot assays are specific, accurate, sensitive, precise & robust. This bioassay is recognised
March 2017: The Antibody Update
Caffeine is an Indirect Anti-Inflammatory Drug Interleukin-1β production is regulated by inflammasomes, a very large protein complex commonly associated with inflammation and pyroptosis. As the human body ages and accumulates metabolites, the inflammasome interacts with them and is primed for
Problems with Immunotherapy
Pairs of proteins that act as T-cell co-signaling receptors are called immune checkpoints. These cell surface receptors can send positive or negative signals to T cells, instigating a response from the immune system to either stimulate the immune system against
T-cell Activation: The Purpose of CD28, CTLA-4, and CD80/CD86
A Guide to CD28, CTLA-4, and CD80/CD86 Interaction and Signaling Immune checkpoint receptors like CD28 and CTLA-4 have been of great interest in the research of cancer immunotherapy. These receptors and their ligands are part of what regulates T-cell activation
Give Your Research 100% With a S100 Antibody
S100 proteins are a family of proteins known for their role in a variety of cellular pathways and diseases. This blog post will catch you up on the latest research on these important proteins. The S100 protein family consists of
Help! My mouse tetramer stained ALL the CD8+ T cells!
You’re sitting at your flow cytometer, staring at your CD8 x tetramer plot in anticipation of a tiny but meaningful group of dots appearing in the upper right quadrant. You hold your breath, click “acquire,” and watch… Wait, what? What’s