Antibody development is multi-faceted process that begins with the target to which you wish to develop antibodies against: the antigen. To elicit an immune response we must select the appropriate adjuvant to be mixed with the antigen for immunization. Which
Antibody Basics: Hybridoma
Hybridoma Development Hybridoma technology is the core technique used to develop monoclonal antibodies at ProSci. A hybridoma is a single cell that consists of a cancerous myeloma cell and an immune B-cell which have been fused together into a single
Antibodies & Targets: An Introduction to SAMHD1
SAMHD1, or Sterile Alpha Motif and Histidine/Aspartate domain-containing protein 1, is a dimeric enzyme with phosphohydrolase and nuclease activity that functions as a blockade for virus replication in dendritic cells, monocytes, and macrophages. Its activity is regulated through phosphorylation of
Searching for the Heart of the Problem: Antibodies to Cardiac Myosin Binding Protein
ProSci works with Dr. Sadayappan to create a set of custom antibodies used to study cardiomyopathy. Cardiac Myosin Binding Protein-C (cMyBP-C) is a protein present in cardiac muscle that has been shown to affect the organizational structure of the muscle
Antibody Suppresses AIDS Virus
News from ProSci: Results from a new trial found that an “extremely potent” antibody can dramatically reduce the level of the HIV virus in a patient’s blood. An H9 T cell, blue, is shown infected with HIV, yellow. Researchers at