An article published by Nature earlier this year pointed out that researchers now have to worry about the reproducibility of production antibodies. The fact of the matter is that off-the-shelf antibodies from large distributors can be unreliable tools, often functioning
ProSci’s 5 A’s of Antibody Development Infographic
Antibody development is multi-faceted process that begins with the target to which you wish to develop antibodies against: the antigen. To elicit an immune response we must select the appropriate adjuvant to be mixed with the antigen for immunization. Which
Antibody Basics: Hybridoma
Hybridoma Development Hybridoma technology is the core technique used to develop monoclonal antibodies at ProSci. A hybridoma is a single cell that consists of a cancerous myeloma cell and an immune B-cell which have been fused together into a single
Antibody Basics: Monoclonal, Polyclonal, and Recombinant Antibodies
While simple in principle, antibodies are deceivingly complex in structure and production. Do you know the advantages and disadvantages of monoclonal, polyclonal and recombinant antibody production? Let ProSci be your expert. Polyclonal → Monoclonal → Recombinant Polyclonal Antibodies: Polyclonal antibodies are characterized
Antibodies & Targets: An Introduction to SAMHD1
SAMHD1, or Sterile Alpha Motif and Histidine/Aspartate domain-containing protein 1, is a dimeric enzyme with phosphohydrolase and nuclease activity that functions as a blockade for virus replication in dendritic cells, monocytes, and macrophages. Its activity is regulated through phosphorylation of
Searching for the Heart of the Problem: Antibodies to Cardiac Myosin Binding Protein
ProSci works with Dr. Sadayappan to create a set of custom antibodies used to study cardiomyopathy. Cardiac Myosin Binding Protein-C (cMyBP-C) is a protein present in cardiac muscle that has been shown to affect the organizational structure of the muscle
Antibody Suppresses AIDS Virus
News from ProSci: Results from a new trial found that an “extremely potent” antibody can dramatically reduce the level of the HIV virus in a patient’s blood. An H9 T cell, blue, is shown infected with HIV, yellow. Researchers at
Does the Llama Hold the Key to HIV Vaccines?
Llamas make especially tiny antibodies that can neutralize 60 strains of HIV. Known for being sturdy and dependable animals, leave it to llamas to deliver some good news in the slow-going quest for an HIV vaccine. (learn more about ProSci’s