Use QuickSwitch™ Class II Quant Tetramer to investigate peptide-MHC binding affinities & conclude with your specialised CD4+ T cell detection reagent!
Streamline the detection of CD4 T cells with QuickSwitch™ Class II Quant Tetramer Kits
Protective Role of Invariant Natural Killer T (iNKT) cells
CD1d, non-classical MHC molecules, present phospholipid & glycosphingolipid antigens to iNKT cells. MBL tetramers help measure CD1d positive NKT cells
Ensure Accurate Immune Monitoring Results with Negative Controls
Negative controls aid precision of immune response monitoring. For HLA-A*02:01 alleles, MBLI offers a “Negative Tetramer” in BV421, PE or APC.
Immune Checkpoints
ProSci offers reagents that can be used to study the actions of multiple immune checkpoint proteins such as CTLA-4, PD-1, & its ligands PD-L1 & PD-L2.
CD1d Tetramers for Monitoring Invariant Natural Killer T (iNKT) cells
MBL International offers CD1d tetramers prepared by tetramerisation of complexes of CD1d and β2m by PE- or APC- labelled streptavidin.
HVEM – BTLA – LIGHT – CD160 Network
The checkpoint receptors/ligands system HVEM, LIGHT, CD160 and BTLA (CD272) is part of a complex network of overlapping receptor interactions.
OX40 – OX40L Pathway
OX40 is an activating receptor expressed on the surface of activated cytotoxic T cells & Tregs. OX40 activates & amplifies T cell responses.
LAG-3 – Major Histocompatibility Complex (MHC) – T Cell Receptor (TCR) Pathway
Dual inhibition of LAG-3 and other checkpoint pathways may synergistically increase T cell antitumour activity.
CTLA-4 [CD152] – CD80 – CD86 – CD28 Network
![CTLA-4 [CD152] – CD80 – CD86 – CD28 Network](https://www.caltagmedsystems.co.uk/information/wp-content/uploads/cd28-600x300.png "CTLA-4 [CD152] – CD80 – CD86 – CD28 Network")
Targeting CTLA-4 restores immune response by more accumulation, function & survival of T cells, depletion of Tregs & better antitumour response.
Butyrophilin-like Proteins & Other Immune Checkpoint Proteins
Human Ig superfamily receptor proteins of the structural & functional diverse BTN & BTNL families are potentially important immune modulators.