KACTUS has demonstrated via ELISA & SPR binding assays that their MHC-peptide complexes & loaded peptide-ready MHCs have good binding affinity to TCRs.
KACTUS: MHC Monomer & Tetramer Product Validation Data
TCR Tetramers
A TCR Tetramer is a reagent prepared by tetramerising biotinylated antigen-specific TCRs with the help of phycobiliprotein-labelled streptavidin.
CD1d
CD1d molecules are non-polymorphic MHC class I-like proteins. These are a type of non-classical MHCs. They present phospholipid and glycosphingolipid antigens to invariant Natural Killer T (iNKT) cells, a subset of CD1d-restricted T cells. This axis is involved in the
MHC Class II Tetramers
T cell receptors (TCRs) expressed on the surface of T cells specifically recognise and bind to complexes of major histocompatibility complex (MHC) molecules and peptide fragments. CD4+ T cells, which include helper and regulatory T cells, recognise complexes of MHC class
Why is the MHC monomer the ideal choice for your experimental design?
The MHC Monomer is a sub-component of an MHC Tetramer. Biotinylated Monomers are available for most associated Tetramer products.
Flexibility and Expansion with BV421 Tetramers
Adding another marker to a flow cytometry panel can present a challenge when trying to accommodate all markers of interest in one panel. However, there is a solution.
QuickSwitch™ Quant Analysis of SARS-CoV-2 mRNA Vaccinations
MBL International provides QuickSwitch™ Tetramers for the Quant Analysis of SARS-CoV-2 mRNA Vaccinations.
Rapid and Reliable Custom Tetramer Generation for T-Cell Staining
MBLI QuickSwitch™ kit technology aims to replicate the immune response by mimicking peptide exchange on an MHC molecule.
Streamline the detection of CD4 T cells with QuickSwitch™ Class II Quant Tetramer Kits
Use QuickSwitch™ Class II Quant Tetramer to investigate peptide-MHC binding affinities & conclude with your specialised CD4+ T cell detection reagent!
Protective Role of Invariant Natural Killer T (iNKT) cells
CD1d, non-classical MHC molecules, present phospholipid & glycosphingolipid antigens to iNKT cells. MBL tetramers help measure CD1d positive NKT cells