Wang, Wenfeng, et al 2023, selected the top 15 top peptides for self-antigen for their study. By using the QuickSwitch™ kit, they successfully switched 6 peptides to the tetramer complex with an efficiency of over 75%.
Negative controls aid precision of immune response monitoring. For HLA-A*02:01 alleles, MBLI offers a “Negative Tetramer” in BV421, PE or APC.
Research findings indicate that neoantigens have the potential to activate tumour-specific T-cell-mediated anti-tumour immune responses.
Investigators have developed a gating strategy that effectively minimises non-specific staining by incorporating a dump channel.
Using nanoparticle technology in making vaccines for infectious diseases/cancer is advancing & enhances the immunogenicity of some vaccine candidates.
In a previous blog post (How to screen SARS-CoV-2 peptides to facilitate T cell research) MBL International described how the immune system samples all of the pathogenic proteins by looking at the small fragments of each protein and determining whether
COVID-19 infected cells can be recognized by T-cells only after SARS-CoV-2 peptides are processed and presented in the context of self MHCs. Identifying these peptides have essential utilities: Immune monitoring: Using peptide-MHC tetramers to assess vaccine-induced immunity Designing potent vaccines
TCRs recognize and bind to complexes composed of MHC molecules and specific peptides expressed on the surface of antigen-presenting cells. We have tetramerized and biotinylated with streptavidin to maintain stable binding to multiple TCR, enabling MHC/peptide tetramers to be used
Biotinylated MHC monomers, the building blocks of MHC tetramers, are now available for tetramer construction flexibility and novel applications. See All Monomer Products
Fast, High-Quality Generation of New Tetramer Specificities Rapid, high-quality creation of custom class I tetramers is now a reality! Create new specificity tetramers in just a few hours with QuickSwitch™ from MBL International; a proprietary technology for exchanging peptides on