Inflammasomes are large multimolecular complexes involved in innate immune and inflammatory responses. A recent study published by the lab of Prof. Victoriano Mulero (Universidad de Murcia, Spain) describes a new function of the inflammasome as a regulator of the balance between erythroid and myeloid differentiation during hematopoiesis. Activation of the inflammasome and caspase-1 results in the cleavage of the master erythroid transcription factor GATA1, with a decrease in erythrocyte differentiation and in the increase of myeloid cell differentiation.
AdipoGen Life Sciences provides key standard inflammasome research reagents, including Antibodies and Small Molecules. Numerous scientific publications document the quality of our products.
– anti-Caspase-1 (p20) (mouse), mAb (Casper-1) (Prod. No. AG-20B-0042)
– anti-Caspase-1 (p20) (human), mAb (Bally-1) (Prod. No. AG-20B-0048)
– anti-NLRP3/NALP3, mAb (Cryo-2) (Prod. No. AG-20B-0014)
– anti-Asc, pAb (AL177) (Prod. No. AG-25B-0006)
– anti-Caspase-4 /11 (p20), mAb (Flamy-1) (Prod. No. AG-20B-0060)
– anti-NLRP6/NALP6 (human), mAb (Clint-1) (Prod. No. AG-20B-0046)
– MCC950 . sodium salt [NLRP3 Inhibitor] (Prod. No. AG-CR1-3615)
– Monosodium urate (ready-to-use) [NLRP3 Activator] (Prod. No. AG-CR1-3951)
LIT: Inflammasome regulates hematopoiesis through cleavage of the master erythroid transcription factor GATA1: S.D. Tyrkalska, et al.; Immunity 51, 50 (2019)