TargetMol

Kynurenic acid

Product Code:
 
TAR-T65135
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T65135-50mg50mg£95.00
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  • Further Information
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Further Information

Bioactivity:
Kynurenic acid (Quinurenic acid) is an endogenous tryptophan active metabolite, a triple antagonist of NMDA, glutamate, α7 nicotinic acetylcholine receptor, and an agonist of GPR35/CXCR8 with neuroprotective and anticonvulsant properties. It has neuroprotective and anticonvulsant properties and can be used to study neurodegeneration and metabolism-related diseases.
CAS Number:
492-27-3
Formula:
C10H7NO3
Molecular Weight:
189.17
Purity:
100%
SMILES:
O=C(O)C1=NC=2C=CC=CC2C(O)=C1
Target:
GPR; GluR; NMDAR

Documents

References

1.Wang J, et al. Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. J Biol Chem. 2006 Aug 4;281(31):22021-8. 2.Albuquerque EX, et al. Kynurenic acid as an antagonist of ?7 nicotinic acetylcholine receptors in the brain: facts and challenges. Biochem Pharmacol. 2013 Apr 15;85(8):1027-32. 3.Ma?aczewska J, et al. Effect of oral administration of kynurenic acid on the activity of the peripheral blood leukocytes in mice. Cent Eur J Immunol. 2014;39(1):6-13.