TargetMol

Trimethylamine N-oxide

Product Code:
 
TAR-T41245
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T41245-100mg100mg£94.00
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Quantity:
TAR-T41245-1mL1mL£95.00
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  • Further Information
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Further Information

Bioactivity:
Trimethylamine N-oxide (TMAO) is a colorless amine oxide produced from choline, betaine, and carnitine via intestinal microbial metabolism that accumulates in tissues of marine animals and prevents the protein-damaging effects of urea.Trimethylamine N-oxide induces inflammation through activation of ROS/NLRP3 inflammasomes, which can induce fibroblast differentiation and cardiac fibrosis.
CAS Number:
1184-78-7
Formula:
C3H9NO
Molecular Weight:
75.11
Purity:
98%
SMILES:
O=N(C)(C)C
Target:
Reactive Oxygen Species; NOD-like Receptor (NLR); TGF-beta/Smad

Documents

References

1.Wei Shuai, et al. High-choline Diet Exacerbates Cardiac Dysfunction, Fibrosis, and Inflammation in a Mouse Model of Heart Failure With Preserved Ejection Fraction. J Card Fail. 2020 May 14;S1071-9164(19)31802-0. 2.Manuel T velasquez, et al. Trimethylamine N-Oxide: The Good, the Bad and the Unknown. Toxins (Basel). 2016 Nov 8;8(11):326. 3.Wenlong Yang, et al. Gut Microbe-Derived Metabolite Trimethylamine N-oxide Accelerates Fibroblast-Myofibroblast Differentiation and Induces Cardiac Fibrosis. J Mol Cell Cardiol. 2019 Sep;134:119-130.