EnhancedTRAIL Soluble (human) (rec.) Pack
Product Code:
AG-44B-0002
AG-44B-0002
Regulatory Status:
RUO
RUO
Target Species:
- Human
- Mouse
Shipping:
Blue Ice
Blue Ice
Storage:
-20°C
-20°C
No additional charges, what you see is what you pay! *
| Code | Size | Price |
|---|
| AG-44B-0002-KI01 | 1 Set | £410.00 |
Quantity:
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This product comes from: Switzerland.
Typical lead time: 7-10 working days.
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Typical lead time: 7-10 working days.
Contact us for more accurate information.
- Further Information
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Further Information
Alternate Names/Synonyms:
Apo-2L; TNFSF 10; CD253
EClass:
32160000
Handling Advice:
After reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.
Kit Contains:
2x10µg TRAIL, Soluble (human) (rec.) (Prod. No. AG-40B-0003) | 3x50µg TNF Ligands Enhancer (Prod. No. AG-35B-0001)
Long Description:
Set. Induces apoptosis in a concentration range of 5-50ng/ml in the presence of 1µg/ml of TNF Ligands Enhancer (Prod. No. AG-35B-0001).
Other data:
Source/Host: Produced in E. coli. A FLAG®-tag is fused at the N-terminus of the extracellular domain of human TRAIL (aa 95-281).Concentration: TRAIL: 0.1mg/ml after reconstitutionTNF Ligands Enhancer: 1mg/ml after reconstitutionPurity: >95% (SDS-PAGE)Formulation:Lyophilized. Contains PBS.Endotoxin Content:TRAIL: <0.01EU/µg purified protein (LAL test; Lonza).TNF Ligands Enhancer: <0.01EU/µg purified protein (LAL test; Lonza).Reconstitution:TRAIL: reconstitute with 100µl sterile water. PBS containing at least 0.1% BSA should be used for further dilutions.TNF Ligands Enhancer: reconstitute each vial with 50µl sterile water. PBS containing at least 0.1% BSA should be used for further dilutions.
Package Type:
Plastic Vial
Product Description:
Induces apoptosis in a concentration range of 5-50ng/ml in the presence of 1µg/ml of TNF Ligands Enhancer (Prod. No. AG-35B-0001).
Specificity:
Binds to human and mouse TRAIL receptors and human osteoprotegrin (OPG).
Transportation:
Non-hazardous
UNSPSC Category:
General Purpose Cell Biology Kits
UNSPSC Number:
41116111
Use & Stability:
Stable for at least 6 months after receipt when stored at -20°C.
Documents
References
Sensitivity to TRAIL/APO-2L-mediated apoptosis in human renal cell carcinomas and its enhancement by topotecan: M. Dejosez, et al.; Cell Death Differ. 7, 1127 (2000) | Three adenovirus E3 proteins cooperate to evade apoptosis by tumor necrosis factor-related apoptosis-inducing ligand receptor-1 and -2: C.A. Benedict et al.; J. Biol. Chem. 276, 3270 (2001) | The anti-apoptotic protein BAG-3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines: Q. Liao, et al.; FEBS Lett. 503, 151 (2001) | Caspase-10 is an initiator caspase in death receptor signaling: J. Wang, et al.; PNAS 98, 13884 (2001) | Tumor necrosis factor-related apoptosis-inducing ligand-induced death-inducing signaling complex and its modulation by c-FLIP and PED/PEA-15 in glioma cells: C. Xiao, et al.; J. Biol. Chem. 277, 25020 (2002) | TRAIL and its receptors in the colonic epithelium: a putative role in the defense of viral infections: J. Strater, et al.; Gastroenterology 122, 659 (2002) | TRAIL/Apo-2 ligand induces primary plasma cell apoptosis: J. Ursini-Siegel, et al.; J. Immunol. 169, 5505 (2002) | Induction of TRAIL-mediated glioma cell death by human T cells: J. Dörr, et al.; J. Neuroimmunol. 122, 117 (2002) | Chemotherapy enhances TNF-related apoptosis-inducing ligand DISC assembly in HT29 human colon cancer cells: S. Lacour, et al.; Oncogene 22, 1807 (2003) | Human mast cells undergo TRAIL-induced apoptosis: B. Berent-Maoz, et al.; J. Immunol. 176, 2272 (2006)