anti-Caspase-1 (p20) (mouse) mAb (Casper-1)
Product Code:
AG-20B-0042
AG-20B-0042
Host Type:
Mouse
Mouse
Antibody Isotype:
IgG1
IgG1
Antibody Clonality:
Monoclonal
Monoclonal
Antibody Clone:
Casper-1
Casper-1
Regulatory Status:
RUO
RUO
Target Species:
Mouse
Mouse
Applications:
- Immunohistochemistry (IHC)
- Immunoprecipitation (IP)
- Western Blot (WB)
Shipping:
Blue Ice
Blue Ice
Storage:
-20°C
-20°C
No additional charges, what you see is what you pay! *
| Code | Size | Price |
|---|
| AG-20B-0042-C100 | 100 ug | £380.00 |
Quantity:
Prices exclude any Taxes / VAT
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: Switzerland.
Typical lead time: 7-10 working days.
Contact us for more accurate information.
Typical lead time: 7-10 working days.
Contact us for more accurate information.
- Further Information
- Documents
- References
- Show All
Further Information
Alternate Names/Synonyms:
Interleukin-1beta Convertase; IL-1BC; Interleukin-1beta-converting Enzyme; ICE
Concentration:
1mg/ml
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Handling Advice:
After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.
Immunogen:
Recombinant mouse caspase-1.
Long Description:
Monoclonal Antibody. Recognizes endogenous full-length and activated (p20 fragment) mouse caspase-1. Isotype: Mouse IgG1. Clone: Casper-1. Applications: IHC, IP, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called Inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3 responds to a variety of agonists including crystals.
NCBI, Uniprot Number:
P29452
Package Type:
Plastic Vial
Product Description:
Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called Inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3 responds to a variety of agonists including crystals.
Purity:
>95% (SDS-PAGE)
Source / Host:
Purified from concentrated hybridoma tissue culture supernatant.
Specificity:
Recognizes endogenous full-length and activated (p20 fragment) mouse caspase-1.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.
Documents
References
Measuring the inflammasome: O. Gross; Methods Mol. Biol. 844, 199 (2012) | Inflammasome Activators Induce Interleukin-1alpha Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1: O. Gross, et al.; Immunity 36, 388 (2012) | Omega-3 Fatty Acids Prevent Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome Activation: Y. Yan, et al.; Immunity 38, 1154 (2013) | LRRFIP2 negatively regulates NLRP3 inflammasome activation in macrophages by promoting Flightless-I-mediated caspase-1 inhibition: J. Jin, et al.; Nat. Commun. 4, 2075 (2013) | iGLuc: a luciferase-based inflammasome and protease activity reporter: E. Bartok, et al.; Nat. Methods 10, 147 (2013) | Receptor interacting protein kinase 2?mediated mitophagy regulates inflammasome activation during virus infection: C. Lupfer, et al.; Nat. Immunol. 14, 480 (2013) | Activation of the NLRP3 inflammasome by IAV virulence protein PB1-F2 contributes to severe pathophysiology and disease: J.L. McAuley, et al.; PLoS Pathog. 9, e1003392 (2013) | Caspase-1 activity affects AIM2 speck formation/stability through a negative feedback loop: C. Juruj, et al.; Front. Cell. Infect. Microbiol. 3, 14 (2013) | Inflammasome Activation by Altered Proteostasis: J.N. Shin, et al.; J. Biol. Chem. 288, 35886 (2013) | Immunoblotting for active caspase-1: C. Jakobs, et al.; Methods Mol. Biol. 1040, 103 (2013) | Inflammasome activation and inhibition in primary murine bone marrow-derived cells, and assays for IL-1alpha, IL-1beta, and caspase-1: K.s. Schneider, et al.; Methods Mol. Biol. 1040, 117 (2013) | FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes: P. Gurung, et al.; J. Immunol. 192, 1835 (2014) | Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection: Md. H. Zaki, et al.; PNAS 111, 385 (2014) | XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation: M. Yabal, et al.; Cell Rep. 7, 1796 (2014) | The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation: B.S. Franklin, et al.; Nat. Immunol. 15, 727 (2014) | The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response: A. Baroja-Mazo, et al.; Nat. Immunol. 15, 738 (2014) | Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation: F. Madouri, et al.; J. Mol. Cell Biol. 7, 351 (2015) | ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways: T. Kuriakose, et al.; Sci. Immunol. 1, aag2045 (2016) | Assessing Caspase-1 Activation: B. Guey & V. Petrilli; Methods Mol. Biol. 1417, 197 (2016) | IL-1beta and caspase-1 drive autoinflammatory disease independently of IL-1alpha or caspase-8 in a mouse model of familial mediterranean fever: D. Sharma, et al.; Am. J. Pathol. 187, 236 (2017) | The DNA inflammasome in human myeloid cells is initiated by a STING-cell death program upstream of NLRP3: M.M. Gaidt, et al.; Cell 171, 1110 (2017) | Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome: M.C. Okondo, et al.; Cell Chem. Biol. 25, 1 (2018) | Complement Mediated Activation of the NLRP3 Inflammasome and its Inhibition by AAV Mediated Delivery of CD59 in a Model of Uveitis: B. Kumar, et al.; Mol. Ther. (2018), doi: 10.1016/j.ymthe.2018.03.012 | IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation: R. Karki, et al.; Cell 173, 1 (2018) | Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity: D. Boucher, et al.; J. Exp. Med. 215, 827 (2018) | N-terminal degradation activates the NLRP1B inflammasome: A.J. Chui, et al.; Science 364, 82 (2019) | Functional degradation: A mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes: Science 364, eaau1330 (2019) | NLRP3 inflammasome activation drives tau pathology: C. Ising, et al.; Nature 575, 669 (2019) | Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense: M. Zheng, et al.; Cell 181, 674 (2020) | Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1beta/NF-kappaB-NLRP3 inflammasome positive feedback loop: F. Chen, et al.; Bone Res. 8, 10 (2020) (Rat Samples) | STING regulates metabolic reprogramming in macrophages via HIF-1alpha during Brucella infection: M.T.R. Gomes, et al.; PLoS Pathog 17, e1009597 (2021) | DDX3X coordinates host defense against influenza virus by activating the NLRP3 inflammasome and type I interferon response: S. Kesavardhana, et al.; J. Biol. Chem. 296, 100579 (2021)