ProSci

CD152 Antibody [UC10-4F10-11] (APC)

Product Code:
 
PSI-76-855
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Hamster
Antibody Isotype:
 
Armenian Hamster IgG
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
UC10-4F10-11
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Flow Cytometry
Storage:
 
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
 

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PSI-76-855-0.1mg0.1mg£536.00
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Further Information

Additional Names:
Cd152, Ly-56, Ctla-4, Ctla4
Background:
The UC10-4F10-11 monoclonal antibody specifically reacts with the mouse Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4), also known as CD152. It is a protein with a structure similar to CD28 regarding the genomic organization, amino acid sequence, and structure. CTLA-4 is expressed on activated T cells and CD25+/CD4+ Treg lymphocytes and binds the members of the B7 family, B7-1 (CD80) and B7-2 (CD86), with higher affinity than CD28. CD28 seems to provide opposing signal to T lymphocytes, while CD152 inhibits the T lymphocytes progression to an activated state and their proliferation, CD28 is a costimulator. The mouse UC10 -4F10-11 monoclonal antibody does not cross-react with the rat leukocytes.
Background References:
  • Herling, M., Teitell, M. A., Shen, R. R., Medeiros, L. J., Jones, D. (2003). TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin.Blood,101(12), 5007-5009.
  • Peduzzi, E., Groeper, C., Schtte, D., Zajac, P., Rondini, S., Mensah-Quainoo, E., ... Daubenberger, C. A. (2007). Local activation of the innate immune system in Buruli ulcer lesions.Journal of Investigative Dermatology,127(3), 638-645.
  • Sun, Q., Woodcock, J. M., Rapoport, A., Stomski, F. C., Korpelainen, E. I., Bagley, C. J., ... Lopez, A. F. (1996). Monoclonal antibody 7G3 recognizes the N-terminal domain of the human interleukin-3 (IL-3) receptor alpha-chain and functions as a specific IL-3 receptor antagonist.Blood,87(1), 83-92.
Buffer:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Conjugate:
APC
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
12477
NCBI Official Name:
cytotoxic T-lymphocyte-associated protein 4
NCBI Official Symbol:
Ctla4
NCBI Organism:
Mus musculus
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Area:
Immunology
SPECIFICITY:
The UC10-4F10-11 monoclonal antibody specifically reacts with the mouse Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4), also known as CD152.
Swissprot #:
P09793
User NOte:
Optimal dilutions for each application to be determined by the researcher.