Sciencell

GeneQuery™ Human Fibroblast Growth Factor Signaling Pathway qPCR Array Kit

Product Code:
 
SC-GK040
Product Group:
 
PCR Kits
Supplier:
 
Sciencell
Host Type:
 
Human
Regulatory Status:
 
RUO
1 / 1
❮❯

No additional charges, what you see is what you pay! *

CodeSizePrice
SC-GK0401 kit£297.00
Please contact us with your Instrument Model Type to ensure ordering of the correct kit version.
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: United States.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • Related Products
  • Show All

Further Information

Description:
ScienCell's GeneQuery™ Human Fibroblast Growth Factor Signaling Pathway qPCR Array Kit (GQH-FGF) is designed to facilitate gene expression profiling of 88 key genes involved in Fibroblast Growth Factor (FGF) signaling pathways. FGFs are involved in a wide variety of biological functions such as embryonic development, organogenesis, angiogenesis, tissue regeneration and wound healing. Through their binding with FGF receptors (FGFRs), FGFs activate and regulate many downstream signaling pathways, such as MAPK, JNK and STAT/NF-κB. Brief examples of how included genes may be grouped according to their functions are shown below:

Secreted FGFs -

  • FGF1 superfamily: - FGF1, FGF2
  • FGF4 superfamily: - FGF4, FGF5
  • FGF7 superfamily: - FGF3, FGF7, FGF10
  • FGF8 superfamily: - FGF17, FGF18
  • FGF9 superfamily: - FGF9, FGF16, FGF20
  • Endocrine FGFs: - FGF19, FGF23
  • Intracellular FGFs: - FGF13, FGF14
  • FGF receptors: - FGFR1, FGFR2, FGFR3, FGFR5
  • FGF signaling inhibitors: - IL17RD, SPRY2, SPRY4, PTPN1, DUSP1, DUSP6

Activated downstream pathways -

  • MAPK pathway: - FRS2, GAB1, SOS1, PTPN11, SHC1, RAS, BRAF, MAPK1, MAPK3, MAP2K1, MAP2K2
  • PI3K/AKT pathway: - AKT1, AKT2, AKT3, PI3Ks, FOXO1, FOXO3, BAD, BAX, CASP9
  • JNK pathway: - MAPK8, MAPK9, MAPK14, RAC1, ATF2, MAP2K4, MAP2K6
  • STAT/NF- - κB pathway: - STAT1, STAT3, NFKB1, NFKB2, REL, MMP9
GeneQuery™ qPCR array kits are qPCR ready in a 96-well plate format, with each well containing one primer set that can specifically recognize and efficiently amplify a target gene's cDNA. The carefully designed primers ensure that: (i) the optimal annealing temperature in qPCR analysis is 65°C (with 2 mM Mg^2+ , and no DMSO); (ii) the primer set recognizes all known transcript variants of target gene, unless otherwise indicated; and (iii) only one gene is amplified. Each primer set has been validated by qPCR with melt curve analysis, and gel electrophoresis.
Extra Description:
This kit is designed to facilitate gene expression profiling of 88 key genes involved in Fibroblast Growth Factor (FGF) signaling pathways. FGFs are involved in a wide variety of biological functions such as embryonic development, organogenesis, angiogenesis, tissue regeneration and wound healing.